Product description
17-phenyl trinor Prostaglandin F2a ethyl amide-d4 (17-phenyl trinor PGF2a ethyl amide-d4) is intended for use as an internal standard for the quantification of 17-phenyl trinor PGF2a ethyl amide (Item No. 16820) by GC- or LC-MS. 17-phenyl trinor PGF2a ethyl amide is sold under the Allergan trade name Bimatoprost and is an F-series PG analog which has been approved for use as an ocular hypotensive drug.{8941} Investigations in our lab have shown that 17-phenyl trinor PGF2a ethyl amide is converted by an amidase enzymatic activity in the bovine and human cornea to yield the corresponding free acid, with a conversion rate of about 40 µg/g corneal tissue/24 hours.{9311} The free acid, 17-phenyl trinor PGF2a, is a potent FP receptor agonist.{2058,1374} In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.
Specifications
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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17-phenyl trinor Prostaglandin F2a ethyl amide-d4

316820-1

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17-phenyl trinor Prostaglandin F2a ethyl amide-d4

316820-1

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