17-phenyl trinor Prostaglandin F2a-d4

17-phenyl trinor Prostaglandin F2a-d4 (17-phenyl trinor PGF2a-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 17-phenyl trinor PGF2a by GC- or LC-mass spectrometry. 17-phenyl trinor PGF2a is a metabolically stable analog of PGF2a and is a potent agonist for the FP receptor. It binds to the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2a.{2058} At the rat recombinant FP receptor expressed in CHO cells 17-phenyl trinor PGF2a inhibits PGF2a binding with a Ki of 1.1 nM.{1374} The isopropyl ester of 17-phenyl trinor PGF2a-d4 is slightly better than PGF2a isopropyl ester in reducing the intraocular pressure in the cat eye without any irritation.{1107}