Product description
8-iso PGF2a-d4 is intended for use as an internal standard for the quantification of 8-iso PGF2a by GC- or LC-mass spectrometry. 8-iso Prostaglandin F2a (8-iso PGF2a) is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids.{320,371,855} It circulates in human plasma in two distinct forms - esterified in LDL phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF2a level of about 150 pg/ml in normal volunteers. In normal human urine, 8-iso PGF2a levels are about 180-200 pg/mg of creatinine.{320,371} 8-iso PGF2a is a weak TP receptor agonist in vascular smooth muscle.{6640} Conversely, 8-iso PGF2a inhibits platelet aggregation induced by U-46619 (10-6 M) and I-BOP (3 x 10-7 M) with IC50 values of 1.6 x 10-6 M and 1.8 x 10-6 M, respectively.{855}
Specifications
CAS number
211105-40-7
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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8-iso Prostaglandin F2a-d4

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