Prostaglandin F2a-d4

Prostaglandin F2a-d4 (PGF2a-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGF2a (Item No. 16010) by GC- or LC-mass spectrometry. PGF2a is a widely distributed prostaglandin occurring in many species.{187,421,796} It causes contraction of vascular, bronchial, intestinal, and myometrial smooth muscle, and also exerts potent luteolytic activity.{187} PGF2a exhibits its receptor mediated physiological activity at 50-100 nM.{187} Maximal ovine myometrial contraction can be achieved at 125 nM PGF2a in vitro.{1651}