(+)-d-Tocopherol

(+)-d-Tocopherol is a biologically active form of vitamin E, a lipid-soluble antioxidant that protects cellular membranes from oxidative damage.{8199,13784} It reduces cumene hydroperoxide-induced lipid peroxidation in hepatocytes when used at a concentration of 20 µM but induces lipid peroxidation in hepatic microsomes at 100 µM.{54400} (+)-d-Tocopherol (40 µM) decreases capillary formation of HMEC-1 blood endothelial cells.{54401} It also decreases the expression of VCAM in, and the invasiveness of, HMEC-1 cells. (+)-d-Tocopherol (10 µM) reduces estrogen-induced increases in the expression of the estrogen-responsive genes encoding TFF/pS2, cathepsin D, PGR, CITED1, and SERPINA1 and the levels of 8-hydroxy-2’-deoxyguanosine (8-oxo-dG) and nitrotyrosine in MCF-7 breast cancer cells.{54402} Dietary administration of (+)-d-tocopherol (0.2%) reduces tumor growth in an estrogen-supplemented MCF-7 mouse xenograft model. [Matreya, LLC. Catalog No. 1790]