Product description
1-B-D-Glucosylsphingosine is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucocerebrosides (Item Nos. 23206 | 23207 | 25850).{41130} They are formed when sphingosines undergo glucosidation by UDP-glucose.{41131} Glucosylsphingosines completely reduce neurite outgrowth and induce death of LA-N-2 cells when used at concentrations of 10 and 50 ?M, respectively. They also decrease the activity of glucocerebrosidase in LA-N-2 cells in a concentration-dependent manner. Glucosylsphingosine levels are elevated in patients with Gaucher's disease, both in the spleen (in types 1, 2, and 3) and brain (types 2 and 3), thus, glucosylsphingosine has been used as a key biomarker of the disease.{41130,41132} This product contains 1-B-D-glucosylsphingosine (d18:1) isolated from bovine buttermilk. As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1306]
Specifications
CAS number
52050-17-6
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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