2-O-a-D-Glucopyranosyl-L-ascorbic Acid

2-O-a-D-Glucopyranosyl-L-ascorbic acid (AA-2G) is a glucosylated derivative of L-ascorbic acid (Item No. 14656) that has antioxidant and radioprotective activities.{54442,54443,54444} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (EC50 = 61 ?M in 60% ethanol).{54442} AA-2G (5 mM) inhibits y-radiation-induced cell death in CHO-10B2 and radiosensitive xrs5 cells, as well as UVC- or broadband UVB-induced cell death in CHO-10B2 and UV-sensitive UV135 cells.{54443} It is hydrolyzed to ascorbic acid by a-glucosidase and increases serum levels of ascorbic acid in rats and guinea pigs when administered orally at doses of 19.2 and 96 mg/animal, respectively.{54444} AA-2G (19.2 mg/animal per day) reverses weight loss and inhibits subcutaneous hemorrhage in guinea pigs fed a vitamin C-deficient diet.