5-Methoxycanthinone

5-Methoxycanthinone is an alkaloid that has been found in L. floridana and has anticancer properties.{60001} It is cytotoxic to KB, A549, and HCT-8 cells (EC50s = 2.9, 3.1, and 2.5 µg/ml, respectively). It is active against the P. falciparum mefloquine-resistant strain F32 and the multidrug and chloroquine-resistant strain K1 (IC50s = 10.4 and 5.1 µg/ml, respectively).{60005} However, it increases the parasite load by 68.4% in a mouse model of leishmaniasis when administered at a dose of 10 mg/kg per day.{60006}