5-methoxy-DL-Tryptophan

5-methoxy-DL-Tryptophan (DL-5-MTP) is an active metabolite of tryptophan with anti-inflammatory and anticancer activities.{54528,54529} It reduces LPS-induced expression of COX-2, TNF-a, IL-1B, and IL-6 in RAW 264.7 macrophages when used at a concentration of 50 mM.{54529} DL-5-MTP (23.4 mg/kg) increases survival in a mouse model of LPS-induced endotoxemia and a mouse model of sepsis induced by cecal ligation and puncture. It also reduces tumor growth and the number of metastases in an A549 mouse xenograft model when administered at a dose of 100 mg/kg.{54528}