14-Deoxyandrographolide is a diterpene lactone that has been found in A. paniculata and has diverse biological activities, including anticancer, hepatoprotective, antioxidative, and antidiabetic properties.{58034},{58035},{58036},{58037} It inhibits the growth of HL-60 cells with a GI50 value of 25.46 µM and is cytotoxic to T47D cells (EC50 = 2.8 µg/ml) but not HepG2 or NCI H23 cells (EC50s = 28.3 and 26.4 µg/ml, respectively).{58034},{58035} 14-Deoxyandrographolide (10 and 25 µM) increases AMPK phosphorylation and glucose uptake in L6 myotubes and potentiates the effect of insulin to increase cell surface levels of GLUT4 in L6-GLUT4myc cells.{58037} It reduces blood glucose levels in rats in a model of streptozotocin-induced diabetes and in db/db diabetic mice when administered at a dose of 100 mg/kg. 14-Deoxyandrographolide reduces ethanol-induced hepatotoxicity in rats when administered at a dose of 15 mg/kg per day for the last four weeks of an eight-week ethanol exposure period.{58036} It also reduces protein carbonyl and thiobarbituric acid reactive substances (TBARS) levels and increases total glutathione (GSH) levels in isolated rat hepatocytes in the same model.