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(-)-Rolipram
31111-1
1 mg
€46
Product description
(-)-Rolipram is a phosphodiesterase 4 (PDE4) inhibitor (IC50 = 0.22 µM for the guinea pig eosinophil enzyme) and an enantiomer of (+-)-rolipram (Item No. 10011132).{52638} It enhances isoprenaline-induced cAMP accumulation in isolated guinea pig eosinophils (EC50 = 0.19 µM). (-)-Rolipram (1-1,000 µM) inhibits TNF and INF-y production in L1402 CD4+ encephalitogenic rat T cells.{52639} It inhibits ovalbumin-induced contraction of tracheal rings isolated from ovalbumin-sensitized guinea pigs when used at a concentration of 1 µM.{52640} (-)-Rolipram inhibits ovalbumin-induced bronchoconstriction in guinea pigs (ED50 = 0.25 mg/kg).
Specifications
CAS number
85416-75-7
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C
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(-)-Rolipram
31111-1
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