8(E),10(E),12(Z)-Octadecatrienoic Acid

8(E),10(E),12(Z)-Octadecatrienoic acid is a conjugated polyunsaturated fatty acid (PUFA) that has been found in C. officinalis seed oil and has anticancer activity.{61038,37085,30029} It inhibits the growth of Caco-2 cells when used at concentrations ranging from 10 to 50 µM.{37085} 8(E),10(E),12(Z)-Octadecatrienoic acid (10 µM) induces formation of thiobarbituric acid reactive substances (TBARS) and apoptosis in DLD-1 colorectal adenocarcinoma cells.{30029} It also inhibits prostaglandin biosynthesis in sheep vesicular gland microsomes (IC50 = 31 µM).{61039}