PF-9366 is an inhibitor of methionine adenosyltransferase 2A (Mat2A; IC50 = 420 nM for S-adenosyl-L-methionine (SAM) production in an enzyme assay).{54128} It is selective for Mat2A over a panel of neurotransmitter transporters, phosphodiesterases, ion channels, and G protein-coupled receptors, as well as a panel of 39 kinases at 10 uM. PF-9366 inhibits SAM production in H520 lung carcinoma cells (IC50 = 1.2 uM) and Huh7 hepatocellular carcinoma cells (IC50 = 225 nM).
25 mg
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Cayman Chemical
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