Ebastine-d5 is intended for use as an internal standard for the quantification of ebastine (Item No. 15372) by GC- or LC-MS. Ebastine is a potent second generation histamine H1 receptor antagonist (IC50 = 45 nM) that does not cross the blood brain barrier.{24986} It undergoes extensive first-pass metabolism by hepatic cytochrome P450 3A4 into its active carboxylic acid metabolite, carebastine (Item No. 23076), which exerts most of the pharmacological effects.{24985} At 10 ?M, ebastine has been shown to inhibit T cell proliferation and the production of Th2-type pro-inflammatory cytokines by macrophages.{24987}
Specifications
Size
1 mg
CAS number
1216953-13-7
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C