Carebastine-d5 is intended for use as an internal standard for the quantification of carebastine (Item No. 23076) by GC- or LC-MS. Carebastine is an active metabolite of ebastine (Item No. 15372).{24985,34756} Ebastine undergoes extensive first-pass metabolism by the hepatic cytochrome P450 (CYP) isomer CYP3A4 into carebastine, which acts as an antagonist at histamine H1 receptors (IC50 = 45 nM).{34756,24986} Carebastine decreases production of RANTES/CCL5 and monocyte chemoattractant protein 1 (MCP-1/CCL2) in human nasal epithelial cells (HNECs) isolated from patients with nasal allergies.{41052}
1 mg
CAS number
Cayman Chemical
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