Phenazine is a free radical generator.{56020} It has been used as an electron transfer reactant in cell viability assays.{56021} Phenazine (10 uM) induces ssDNA break formation in the presence of the reducing agent NADPH in a cell-free plasmid cleavage assay when used at a concentration of 10 uM. It induces oxidative DNA damage in an alkaline comet assay and apoptosis in A375 melanoma cells when used at a concentration of 10 uM. Phenazine (20 nM) oxidizes cysteine-containing proteins in HepG2 cells.{56020}
10 g
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Cayman Chemical
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