Moguisteine is a peripherally acting antitussive agent.{49654,49655} It inhibits the citric acid-induced cough reflex in conscious guinea pigs but not the cough reflex induced by electrical stimulation of the afferent superior laryngeal nerve in anesthetized guinea pigs (ED50s = 5.5 and >20 mg/kg, respectively).{49655} Moguisteine (75 and 150 mg/kg, p.o.) prevents bronchoalveolar lavage fluid (BALF) eosinophil and neutrophil infiltration in an ovalbumin-sensitized guinea pig model of allergic airway inflammation.{49656} It inhibits increases in tracheal and bronchial plasma exudation induced by cigarette smoke in anesthetized guinea pigs when administered at a dose of 30 mg/kg.
100 mg
CAS number
Cayman Chemical
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