Homatropine (hydrobromide)

Homatropine is an anticholinergic agent.{55132,55130} It reduces acetylcholine-induced contractions of isolated goat detrusor muscle strips when used at a concentration of 5 uM.{55132} Homatropine (1 uM) inhibits acetylcholine- or methacholine-induced contraction of isolated rat anococcygeus muscle.{55130} It inhibits serotonin- or thrombin-induced platelet aggregation in isolated sheep platelet-rich plasma (IC50s = 4.3 and 100 uM, respectively).{55131} Topical ophthalmic administration of homatropine induces partial mydriasis in Angora goats.{55133}