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L-655,708
30322-5
5 mg
€131
Product description
L-655,708 is a ligand for a5 subunit-containing GABAA receptors that has nootropic activity.{56024} It selectively binds to a5 subunit-containing GABAA receptors over a1, a2, or a3 subunit-containing receptors (Kis = 1, 70, 48, and 31 nM, respectively, for recombinant human receptors). L-655,708 (10 nM) increases the amplitude of extracellular post-synaptic potentials (EPSPs) in mouse hippocampal slices. In vivo, L-655,708 (1.5 mg/animal) decreases the latency to find the platform and increases time spent in the target quadrant in the Morris water maze in mice.
Specifications
CAS number
130477-52-0
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C
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30322-5
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