Palmatine is an alkaloid that has been found in C. rhizoma and has diverse biological activities.{47685,52524,52525,52526,52527} It inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE; IC50s = 0.51 and 6.84 uM, respectively).{47685} Palmatine (20, 40, and 80 uM) reduces Zika virus infection of Vero cells in a concentration-dependent manner.{52524} In vivo, palmatine (50 and 100 mg/kg) reduces colonic myeloperoxidase (MPO) activity and IL-10, IL-1B, IL-6, and TNF-a levels, as well as protects mucosal integrity in a mouse model of colitis induced by dextran sulfate (DSS; Item No. 23250).{52525} It reduces stomach ulcer area in a rat model of acetic acid-induced gastric ulcers.{52526} Palmatine (10 and 20 mg/kg) reduces the number of small intestine and colon tumors in the ApcMin+/- mouse model of multiple intestinal neoplasia.{52527}
5 g
CAS number
Cayman Chemical
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