Palmatine (chloride)

Palmatine is an alkaloid that has been found in C. rhizoma and has diverse biological activities.{47685,52524,52525,52526,52527} It inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE; IC50s = 0.51 and 6.84 µM, respectively).{47685} Palmatine (20, 40, and 80 µM) reduces Zika virus infection of Vero cells in a concentration-dependent manner.{52524} In vivo, palmatine (50 and 100 mg/kg) reduces colonic myeloperoxidase (MPO) activity and IL-10, IL-1B, IL-6, and TNF-a levels, as well as protects mucosal integrity in a mouse model of colitis induced by dextran sulfate (DSS; Item No. 23250).{52525} It reduces stomach ulcer area in a rat model of acetic acid-induced gastric ulcers.{52526} Palmatine (10 and 20 mg/kg) reduces the number of small intestine and colon tumors in the ApcMin+/- mouse model of multiple intestinal neoplasia.{52527}