Pulchinenoside B4

Pulchinenoside B4 is a triterpenoid glycoside that has been found in P. chinensis and has diverse biological activities.{48998,48999} It inhibits cisplatin-induced apoptosis, increases in reactive oxygen species (ROS) production, and decreases in superoxide dismutase (SOD) and catalase activities in HEK293 cells when used at concentrations of 6 and 12 ?M.{48998} Pulchinenoside B4 (50 and 100 mg/kg twice per day) prevents increases in plasma blood urea nitrogen (BUN) and creatinine levels, markers of kidney injury, in a mouse model of cisplatin-induced nephrotoxicity. It prevents xylene-induced ear edema in mice in a dose-dependent manner.{48999} Pulchinenoside B4 (50 mg/kg) inhibits LPS-induced increases in serum TNF-a, IL-6, and IL-1B levels a mouse model of LPS-induced systemic inflammation.