CNX-1351 is a covalent inhibitor of PI3Ka (IC50 = 6.8 nM).{56002} It is selective for PI3Ka over PI3KB, -y, and -D (IC50s = 166, 240.3, and 3,020 nM, respectively), as well as PI3KC2A, PI3KC, PI4Ka, PI4KB, SPHK1, and SPHK2 (IC50s = >1 uM for all). CNX-1351 (500 nM) inhibits phosphorylation of Akt in SKOV3 cells. It inhibits the growth of SKOV3 and MCF-7 cancer cells (GI50s = 77.6 and 54.7 nM, respectively). CNX-1351 (100 mg/kg) inhibits Akt phosphorylation in mouse spleen.
Specifications
Size
25 mg
CAS number
1276105-89-5
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C