Irsogladine is a gastroprotective agent.{55063,55064,55065} It increases transfer of Lucifer yellow CH (Item No. 25573) between isolated rabbit gastric epithelial cells, indicating enhanced gap junction intercellular communication (GJIC).{55064} Irsogladine (3 mg/kg) inhibits gastric mucosal lesion formation and decreases in gastric mucosal blood flow induced by monochloramine in rats, effects that can be prevented by the nitric oxide synthase inhibitor L-NAME (Item No. 80210).{55063} It also inhibits superoxide anion production induced by fMLP (Item No. 21495) and increases cAMP levels in isolated human neutrophils in a concentration-dependent manner, similar to the phosphodiesterase 4 (PDE4) inhibitor rolipram (Item No. 10011132).{55065}
Specifications
Size
500 mg
CAS number
84504-69-8
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C