Product description
SKF 86002 is an anti-inflammatory agent.{53596,16230,53597,53598} It inhibits rat seminal vesicle prostaglandin H2 (PGH2) synthase (IC50 = 120 µM), as well as prostanoid production by rat basophilic leukemia (RBL-1) cells and human monocytes (IC50s = 70 and 1 µM, respectively).{53596} SKF 86002 inhibits leukotriene B4 (LTB4) and LTC4 production induced by A23187 (Item No. 11016) in human neutrophils and monocytes, respectively (IC50 = 20 µM for both). It also inhibits LPS-induced IL-1 production in human monocytes (IC50 = 1.3 µM).{16230} SKF 86002 (10, 30, and 90 mg/kg) reduces hindleg volume in rat models of adjuvant- or collagen-induced arthritis.{53597} It also decreases serum levels of TNF-a and increases survival in a mouse model of LPS and galactosamine-induced endotoxic shock when administered at a dose of 100 mg/kg.{53598}
Specifications
CAS number
72873-74-6
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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