ML154 is an antagonist of the neuropeptide S receptor (NPSR; IC50 = 3.5 nM).{46808} It is selective for NPSR over arginine vasopressin (AVP) receptor V1B, as well as a panel of 55 receptors, channels, and transporters at 10 uM.{46809,46808} ML154 reduces NPS-induced calcium mobilization, cAMP formation, and ERK activation with IC50 values of 0.96, 45, and 1.3 nM, respectively, in CHO cells expressing NPSR.{46808} It reduces alcohol self-administration and the progressive ratio breakpoint, but not cue- or stress-induced reinstatement of alcohol-seeking behavior, in rats when administered intraperitoneally at a dose of 1 mg/kg.{46809} ML154 (10 ug, i.c.v.) inhibits decreases in food intake induced by intracerebroventricular administration of NPS in rats.{46808}
10 mg
CAS number
Cayman Chemical
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