Avridine

Avridine is a synthetic lipid amine that acts as an adjuvant.{48943} Subplantar injection of avridine induces paw swelling, an effect that can be blocked by the non-steroidal anti-inflammatory drug (NSAID) phenylbutazone (Item No. 70400) or the alkylating agent cyclophosphamide (Item No. 13849), in rats. Avridine induces paw joint tissue destruction, bone and pannus formation, and neutrophil, fibroblast, and osteoclast infiltration in the same model. It also increases the number of CD4+ T and MHC class II+ cells in rat paws when administered at a dose of 1.5 mg/animal.{48944} Avridine has been used to induce experimental rheumatoid arthritis in rats.{48944,48945,48946}