Tigogenin is a steroidal sapogenin that has been found in A. sisalana and has diverse biological activities.{38813,46840,46841,46842} It increases the proliferation rate of, as well as mRNA levels of genes encoding the osteoblastic differentiation markers Cbfa1, collagen type I, and osteocalcin in, mouse bone marrow stromal cells (BMSCs) in a concentration-dependent manner.{46840} It also increases matrix calcium deposition in BMSCs when used at concentrations of 30 and 90 ?M. Tigogenin is active against the fungus A. fumigatus (MIC50 = 16 ?g/ml).{46841} It inhibits carrageenan-induced paw edema in rats when administered at a dose of 4.2 ?g/kg.{46842}
Specifications
Size
10 mg
CAS number
77-60-1
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C