Ilaprazole is a proton pump inhibitor that inhibits H+/K+-ATPase activity in isolated rabbit gastric mucosa (IC50 = 6 uM).{48937} In vivo, ilaprazole reduces gastric acid secretion induced by pentagastrin (Item No. 28546) or histamine in anesthetized rats (ED50s = 0.38 and 1.2 mg/kg, respectively). It also reduces histamine-induced gastric acid secretion in Heidenhain pouch dogs. Formulations containing ilaprazole have been used in the treatment of peptic ulcers and gastroesophageal reflux disease (GERD).
5 mg
CAS number
Cayman Chemical
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Dry Ice
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