Ilaprazole is a proton pump inhibitor that inhibits H+/K+-ATPase activity in isolated rabbit gastric mucosa (IC50 = 6 uM).{48937} In vivo, ilaprazole reduces gastric acid secretion induced by pentagastrin (Item No. 28546) or histamine in anesthetized rats (ED50s = 0.38 and 1.2 mg/kg, respectively). It also reduces histamine-induced gastric acid secretion in Heidenhain pouch dogs. Formulations containing ilaprazole have been used in the treatment of peptic ulcers and gastroesophageal reflux disease (GERD).
25 mg
CAS number
Cayman Chemical
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Dry Ice
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