Neotuberostemonine is an alkaloid originally isolated from S. tuberosa that has diverse biological activities.{55083,55084,55085} It inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS) protein levels and NO production in RAW 264.7 cells when used at a concentration of 100 uM.{55083} Neotuberostemonine (50 uM) inhibits RANKL-induced osteoclast differentiation of RAW 264.7 cells.{55084} It reduces the citric acid-induced cough reflex in conscious guinea pigs when administered at a dose of 133 umol/kg.{55085} Neotuberostemonine (40 mg/kg) inhibits pulmonary collagen deposition and fibrosis, as well as bronchoalveolar lavage fluid (BALF) monocyte and lymphocyte infiltration in a mouse model of bleomycin-induced pulmonary fibrosis.{55083}
Specifications
Size
5 mg
CAS number
143120-46-1
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C