Germacrone

Germacrone is a sesquiterpene that has been found in gingeraceae plants and has diverse biological activities.{48920,48921,48922,48923} It inhibits pseudorabies virus (PRV) replication in Vero cells when used at concentrations ranging from 10 to 150 µM.{48920} Germacrone (50-250 µM) enhances cytotoxicity and apoptosis induced by doxorubicin (Item No. 15007) in doxorubicin-resistant MCF-7/adr cells.{48921} In vivo, germacrone (5, 10, and 20 mg/kg) reduces body weight gain, visceral fat pad weight, serum insulin and plasma glucose levels, and hepatic lipid levels in a mouse model of high-fat diet-induced obesity.{48922} It decreases brain malondialdehyde (MDA) levels and activity of superoxide dismutase (SOD) and glutathione peroxidase (GPX), as well as reduces infarct volume in a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).{48923}