Forsythoside A is a phenylethanoid glycoside that has been found in F. suspensa and has diverse biological activities.{52386,52387,52388,52389} It is active against E. coli, P. aeruginosa, and S. aureus (MICs = 38.33, 38.33, and 76.67 ug/ml, respectively).{52386} Forsythoside A scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals with an EC50 value of 6.3 ug/ml. It reduces apoptosis induced by amyloid-B (25-35) (AB (25-35)) in PC12 cells when used at concentrations of 10 and 25 uM.{52388} Forsythoside A (15, 30, and 60 mg/kg per day) reduces increases in bronchoalveolar lavage fluid (BALF) levels of TNF-a, IL-6, and IL-1B and neutrophil and macrophage infiltration induced by cigarette smoke in a mouse model of chronic obstructive pulmonary disease (COPD).{52387} It decreases the latency mice take to find the platform in the Morris water maze in the SAMP8 model of rapid aging and dementia when administered at doses of 120 and 240 mg/kg per day.{52389}
Specifications
Size
10 mg
CAS number
79916-77-1
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C