Isocorydine

Isocorydine is an aporphine alkaloid that has been found in A. squamosa that has vasodilatory and anticancer activities.{52447,52448,52449,52450,52451} It reduces the action potential duration and increases the effective refractory period in isolated canine Purkinje fibers when used at a concentration of 30 µM.{52448} Isocorydine induces relaxation of norepinephrine-precontracted isolated rabbit aortic strips with an EC50 value of 12.6 µM.{52449} It is cytotoxic to A549 lung cancer cells (IC50 = 197.7 µM), as well as Huh7, HepG2, SNU-449, and SNU-387 hepatic cancer cells (IC50s = 161.3, 148, 262.2, and 254.1 µg/ml, respectively).{52450,52451} Isocorydine, in combination with doxorubicin, reduces tumor growth in a Huh7 mouse xenograft model.{52451}