2-Hydroxy-4-methoxybenzaldehyde is a phenol found in the root bark essential oil of P. sepium that has diverse biological activities, including antibacterial, antifungal, fungicidal, antioxidant, anti-virulence, and metal chelating properties.{55018,55019,55020} It is active against Gram-positive (MICs = 100-200 ug/ml) and Gram-negative bacteria (MICs = 125-200 ug/ml), as well as the fungus C. albicans and the phytopathogenic fungus M. oryzae (MICs = 150 and 300 ug/ml, respectively). 2-Hydroxy-4-methoxybenzaldehyde scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals in a cell-free assay (IC50 = 9.04 mg/ml) and acts as a metal chelator, inhibiting ferrozine-Fe2+ complex formation with an IC50 value of 2.31 mg/ml. It reduces the production of the virulence factor staphyloxanthin in clinical isolates of methicillin-resistant S. aureus (MRSA) when used at a concentration of 200 ug/ml and decreases the expression of the MRSA virulence regulatory genes saeS, geh, crtM, and sigB.{55019} 2-Hydroxy-4-methoxybenzaldehyde, when used in combination with the antibiotics amikacin (Item No. 15405), gentamicin, cefotaxime (Item No. 16040), vancomycin (Item No. 15327), or tetracycline (Item No. 14328), increases MRSA antibiotic sensitivity. It is also an intermediate in the synthesis of Schiff base-metal complexes with antiproliferative activity.{55020}
Specifications
Size
50 g
CAS number
673-22-3
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C