Pramoxine (hydrochloride)

Pramoxine is a local anesthetic.{46843} It reduces electrically induced peak compound action potential (CAP) amplitudes in isolated frog sciatic nerve (IC50 = 0.21 mM).{46844} Topical administration of pramoxine (0.35 and 0.6%) inhibits winking in a rabbit corneal test, indicating anesthetic activity.{46843} It inhibits the pinprick-induced cutaneous trunci muscle reflex (CTMR) in the skin of rats (ED50 = 42.1 ?mol, s.c.).{46845}