Deltorphin C is a peptide agonist of D-opioid receptors (Ki = 0.15 nM) that has been found in Phyllomedusa bicolor.{46876} It is selective for D-opioid receptors over u- and ?-opioid receptors. It induces D-opioid receptor translocation from large dense-core vesicles to the cell surface and induces calcitonin gene-related peptide (CGRP) release in isolated mouse dorsal root ganglion (DRG) cells when used at concentrations of 0.1 and 1 uM, respectively, effects that can be blocked with the D-opioid receptor antagonist naltrindole (Item No. 9000705).{46877} Intrathecal administration of deltorphin C (0.15, 1.5, and 15 ug/animal) increases latency to withdraw in the paw pressure and tail-flick tests in rats.{46878}
10 mg
Cayman Chemical
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