Legenda image
Western Blotting analysis (reducing conditions) of human Sos using anti-Sos (SOS-01). Lane 1: K562 human Caucasian chronic myeloid leukemia cell line Lane 2: RAJI human Burkitt lymphoma cell line
Product description
The guanine nucleotide exchange factor Sos (Son-of-sevenless) is a complex multidomain protein that activates the small GTPase Ras (H-Ras, K-Ras, N-Ras, but not functionally distinct R-Ras) in response to receptor tyrosine kinase stimulation. Nucleotide exchange activity of Sos is stimulated by allosteric Ras binding. By another (separable) guanine exchange factor domain domain Sos modulates activity of Rac/Rho GTPases. Sos thus integrates signals that affect both gene expression and cytoskeletal reorganization; the Sos-mediated Ras-activation and Rac activation differ in composition and stability of the formed complex.
Specifications
Applications
WB, ICC
Host
Mouse
Clonality
Monoclonal
Clone
SOS-01
Isotype
Mouse IgG1
Supplier
Abeomics
Shipping & storage
Shipping condition
Blue Ice
Storage temperature
2-8°C

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Anti-Sos Monoclonal Antibody (Clone:SOS-01)

30-1360

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Productname

Anti-Sos Monoclonal Antibody (Clone:SOS-01)

30-1360

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