Fusidic acid-d6 is intended for use as an internal standard for the quantification of fusidic acid (Item No. 14825) by GC- or LC-MS. Fusidic acid is a fusidane antibiotic originally isolated from F. coccineum.{54000} It is active against the Gram-positive bacteria S. aureus, S. pyogenes, C. diphtheriae, B. subtilis, and C. tetani (MIC50s = 0.01-20 ug/ml) but not the Gram-negative bacteria E. coli, S. typhimurium, and P. vulgaris or the fungi C. albicans and A. fumigatus (MIC50s = >100 ug/ml for all).{54001} Fusidic acid inhibits ribosomal recycling and protein translocation, processes mediated by elongation factor G (EF-G), in isolated E. coli ribosomes (IC50s = ~0.1 and ~200 uM, respectively).{54002} Topical administration of fusidic acid (2%) reduces the number of skin colony forming units (CFUs) and levels of TNF-a and IL-6 in a mouse model of methicillin-resistant S. aureus (MRSA) skin wound infection.{54003}
500 ug
Cayman Chemical
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