Epalrestat-d5 is intended for use as an internal standard for the quantification of epalrestat (Item No. 15214) by GC- or LC-MS. Epalrestat is an inhibitor of aldose reductase (IC50s = 0.01 and 0.26 uM for rat lens and human placenta aldose reductase, respectively).{53254} It inhibits glucose-induced sorbitol accumulation in isolated rat lens, rat sciatic nerve, and human erythrocytes (IC50s = 1.5, 5, and 1.5 uM, respectively). It decreases high glucose-induced proliferation of vascular smooth muscle cells when used at a concentration of 10 nM and prevents high glucose-induced intracellular NADH/NAD+ increases and membrane-bound PKC activation at 100 nM.{24663,24664} Epalrestat (20 and 40 mg/kg) improves motor nerve conduction velocity and decreases sorbitol content in the sciatic nerve and erythrocytes in a rat model of streptozotocin-induced diabetic neuropathy.{53255} It also prevents capillary strand formation in a rat model of diabetes-induced retinal microangiopathy when administered at a dose of 50 mg/kg.{53256}
Specifications
Size
500 ug
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C