Ajmaline is an alkaloid that has been found in R. serpentina and has ion channel inhibitory and antiarrhythmic activities.{46769,46770,46771,46772,46773} It inhibits the human-ether-a-go-go (hERG) potassium channel, also known as Kv11.1, and the voltage-gated potassium channel subtypes Kv1.5 and Kv4.3 with IC50 values of 42.3, 293, and 186 uM, respectively, in Xenopus oocytes expressing the channels.{46770,46771} Ajmaline (1 ug/ml) increases the action potential duration in isolated dog atrium and ventricle.{46772} It increases the functional refractory duration in the atrium, ventricle, and atrioventricular conduction system in anesthetized dogs when administered intravenously at a dose of 1 mg/kg.{46772} Ajmaline (2 mg/kg, i.v.) reduces the number of premature ventricular complexes and decreases the duration of ventricular tachycardia and ventricular fibrillation in coronary artery-ligated anesthetized rats.{46773}
Specifications
Size
500 mg
CAS number
4360-12-7
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C