Aspulvinone O is a fungal metabolite that has been found in P. variotti and has antioxidant and anticancer activities.{46739,46740} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (IC50 = 11.6 uM).{46739} Aspulvinone O inhibits aspartate transaminase 1 (GOT1; Kd = 3.32 uM) and is cytotoxic to PANC-1, AsPC-1, and SW1990 pancreatic cancer cells (IC50s = 20.54-26.8 uM).{46740} It reduces the oxygen consumption rate (OCR) and induces apoptosis in SW1990 cells. Aspulvinone O (2.5 and 5 mg/kg) reduces tumor growth in an SW1990 mouse xenograft model.
1 mg
CAS number
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature