Sparsomycin

Sparsomycin is a bacterial metabolite and a nucleoside analog of uracil that has been found in S. sparsogenes and has diverse biological activities.{53394,22680,53395} It is active against KB carcinoma cells, Gram-positive and Gram-negative bacteria, and fungi.{53396} Sparsomycin is an inhibitor of peptidyl transferase that interferes with tRNA binding to the A-site of the peptidyl transfer center and increases the binding of peptidyl-tRNA to the P-site.{22680} It inhibits protein synthesis in bacteria, archaea, and eukaryotes.{22680,53395} Sparsomycin reduces tumor growth in a P388 mouse leukemia model and in a Walker 256 carcinosarcoma rat model.{53397}