Galnon is a galanin (GAL) receptor agonist (KD = 2.9 uM in Bowes cells expressing GAL1 receptors).{53507} It inhibits forskolin-induced adenylate cyclase activity in rat hippocampal membranes (EC50 = 10 uM). Galnon (2 mg/kg) reduces the maximal seizure score and increases the latency to first seizure in a mouse model of seizure induced by pentylenetetrazole (PTZ; Item No. 18682). It reduces cocaine-induced motor activity and frontal cortex, but not nucleus accumbens, dopamine overflow, as well as blocks cocaine-primed reinstatement of cocaine-seeking behavior in rats.{53508} Galnon (1.5-5 mg/kg) reduces food intake in rats and mice.{53509}
25 mg
CAS number
Cayman Chemical
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