7,3',4'-Trihydroxyflavone

7,3’,4’-Trihydroxyflavone is a flavonoid that has been found in A. julibrissin bark and has diverse biological activities.{52324,52325,52326,52327} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and peroxynitrite radicals in cell-free assays (IC50s = 2.2 and 5.78 µM, respectively), as well as reduces total reactive oxygen species in rat kidney homogenates (IC50 = 3.9 µM).{52324} 7,3’,4’-Trihydroxyflavone inhibits COX-1 (IC50 = 36.7 µM).{52325} It is active against M. tuberculosis (MIC = 50 µg/ml).{52326} It decreases mRNA expression of the osteoclastic marker genes encoding the calcitonin receptor, cathepsin K1 V-ATPase V0 subunit d2 (Atp6v0d2), and dendritic cell specific transmembrane protein (Dcstamp) in and inhibits RANKL-induced osteoclastic differentiation of mouse bone marrow-derived macrophages (BMDMs).{52327}