(R)-Ofloxacin

(R)-Ofloxacin is a fluoroquinolone antibiotic and the (R) isomer of the antibiotics ofloxacin (Item No. 22891) and levofloxacin (Item No. 20382).{48800} It is active against certain Gram-positive and Gram-negative bacteria, including E. coli, P. aeruginosa strains 32104 and 32122, S. aureus strains 209P and Smith, and S. epidermis strain 56556 (MICs = 0.78, 12.5, 6.25, 25, 12.5, and 25 µg/ml, respectively) but not S. epidermis strain 56500, S. pyogenes, or S. faecalis (MICs = >100 µg/ml for all).{48801} (R)-Ofloxacin inhibits E. coli DNA gyrase with an IC50 value of 75 µg/ml, which is approximately 30- and 50-fold lower than inhibition by ofloxacin and levofloxacin, respectively.{48800}