Product description
3BDO is a butyrolactone derivative and inhibitor of autophagy.{61122,61123} It increases phosphorylation of the mammalian target of rapamycin (mTOR) substrates eIF4E-binding protein 1 (EIF4EBP1) and RPS6KB1/p70S6K1 in human umbilical vein endothelial cells (HUVECs) when used at a concentration of 60 ?M.{61122} 3BDO (60 ?M) also prevents rapamycin-induced MAP1LC3B puncta formation, a marker of autophagy, in HUVECs. It inhibits apoptosis, senescence, and increases in integrin B4 levels induced by serum- and FGF2-deprivation in HUVECs when used at a concentration of 40 ?g/ml.{61124} 3BDO (80 mg/kg per day) reduces cortical and hippocampal amyloid plaque burden, inhibits autophagy in the brain, and rescues learning and memory deficits in the ABPP/PS1 transgenic mouse model of Alzheimer's disease.{61123}
Specifications
CAS number
890405-51-3
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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