2'-Deoxycytidine-5'-monophosphate

2’-Deoxycytidine-5’-monophosphate (dCMP) is a deoxyribonucleotide.{48688} It is formed via phosphorylation of deoxycytidine by deoxycytidine kinase in the cytosol or thymidine kinase 2 (TK2) in mitochondria.{48672,48673} It is further phosphorylated by UMP-CMP kinase to form dCDP (Item No. 22982) during nucleic acid synthesis.{48674} dCMP (700 mg/kg) decreases hydroxyurea-induced neuroepithelial cell necrosis in embryonic mouse spinal cord when administered to pregnant dams.{48675} Oral administration of dCMP in combination with dTMP increases lifespan in a Tk2 H126N knock-in mouse model of TK2 deficiency.{48673}