Product description
2''-O-Galloylhyperin is a natural flavonoid that has been found in P. incarnata and has diverse biological activities, including antioxidant, anti-inflammatory, hepatoprotective, and transporter-inhibiting properties.{53103,53104,53105} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and ABTS (Item No. 27317) radicals (IC50s = 3 and 3.5 ?M, respectively).{53103} It also inhibits human organic anion transporting polypeptide 1B1 (OATP1B1; IC50 = 19 ?M in HEK293 cells).{53104} 2''-O-Galloylhyperin (15 ?M) decreases LPS-induced IL-6 and TNF-a cytokine production from mouse RAW 264.7 macrophages.{53105} It also decreases LPS-induced mortality and liver damage in a mouse model of septic shock when administered at a dose of 50 mg/kg.
Specifications
CAS number
53209-27-1
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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