Product description
(+-)-trans-ACPD is an agonist of metabotropic glutamate receptors (mGluRs; EC50s = 15, 2, 40, 23, and 82 µM for mGluR1, -2, -3, -5, and -6, respectively, in CHO cells expressing recombinant receptors).{47711} It also activates mGluR4 in baby hamster kidney cells with an EC50 value of approximately 800 µM. (+-)-trans-ACPD increases cAMP accumulation in adult rat cerebral cortex slices (EC50 = 47.8 µM) but not in isolated rat embryonic neurons or neonatal glial cells when used at concentrations ranging from 1 to 1,000 µM.{47712} (+-)-trans-ACPD (10-1,000 µM) increases phosphoinositide hydrolysis in neonatal rat cerebral cortex and hippocampal slices. It induces clonic convulsions in neonatal rats (ED50 = 100 mg/kg), an effect that can be reversed by administration of the NMDA receptor antagonists LY233053 and LY274614.{47713}
Specifications
CAS number
67684-64-4
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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